Quote:1. I'm extremely sensitive to chemicals, as in synthetic chemicals in soaps, shampoos, etc.
Skin gets red and blotchy if I use soap or shampoo with SLS in it. Scalp burns with SLS.
Skin got itchy but not red or blotchy from DMSO.
2. I've also used DMSO infrequently over the years, and I have never noticed any of the side-effects you mentioned.
I've also never tasted the "garlic" or sulfur taste on the tongue even using 99% DMSO (topically).
3. Side-Effect Probability: Sick people can have no side-effects and healthy people can have side-effects. What matters is the probability of experiencing those side-effects. Supposedly Finasteride/Propecia/Anti-DHT hairloss drug has a probability of 1-5% for Erectile Dysfunction after using the medication.
If 100 people use Finasteride and only 5 get Erectile Dysfunction, there could be 95 people benefiting from the drug.
If a chemical helps people, why not use it? Especially if the risk of side effects is (x<1%).
4. I agree with you that side-effects need to be taken into consideration before taking any substance, but DMSO is benign. I'm assuming you're equally disturbed by Yohimbe, an extremely unsafe stimulant. I've used Yohimbe and almost had to call an ambulance my heart was racing so fast. And yet there are people who use Yohimbe recreationally or for weight loss or for anti-fatigue purposes.
5. DMSO treats at least one physical medical condition: Interstitial Cystitis (bladder)
I even saw pro-DMSO posters in my urologists office and this urologist is as mainstream as you can get.
Overall, I disagree with you that DMSO is unsafe for the majority of people.
Somo, I think with supplements, or drugs it is important to understand what the molecule is doing, instead of choosing to ingest something based on the manufactures alleged probability of side effects. Haidut is a good example here, as he has consistently lied to his potential customers not only about the side effect profile of DMSO, but by denying that side effects which had been reported to him by myself, had ever been reported by his customers.
Ray Peat has explained that DMSO exerts negative metabolic effects and therefore should not be used for any prolonged duration. In the context of the Ray Peat community, people are attempting to increase their metabolic rates. Therefore, when a compound is found to lower body temperature, raise nitric oxide and histamine, and has the end result of overexciting cells leading to their premature deaths; this is not a compound that I think should be considered helpful or a good idea to experiment with.
You are correct in your assessment that I would not recommend "Yohimbe". I agree with Ray Peat's general stance regarding supplements which I think is well illustrated here:
"Because the quality of commercial nutritional supplements is dangerously low, the only supplement I generally advocate is vitamin E, and that should be used sparingly. Occasionally, I will suggest limited use of other supplements, but it is far safer in general to use real foods, and to exclude foods which are poor in nutrients. Magnesium is typically deficient in hypothyroidism, and the safest way to get it is by using orange juice and meats, and by using epsom salts baths;" (http://www.thyroid-info.com/articles/ray-peat.htm
The FDA may claim that DMSO treats Interstitial Cystitis, but in the Ray Peat community people generally don't subscribe to the pharmaceutical industry's theory of treating each symptom with a different drug or surgical intervention. Certainly, I subscribe to the idea that it is the metabolic rate which determines how fast we heal, and what types of diseases or aging we are susceptible to, and that is a mistake to treat specific problems like Interstitial Cystitis, instead of addressing the overall metabolic rate. Even Haidut has previously debunked the FDA here:
"The FDA has maintained for years that glyphosate is safe but has refused to test food samples for its presence. When public pressure for testing intensified the FDA finally started some tests in 2017 but the process was immediately tested by evidence that a top EPA official involved in the testing was openly collaborating with Monsanto and trying to derail the tests or skew their results. Well, it appears that the FDA is always part of the scam. As the article below shows, while the tests on "official food samples" performed by the FDA did not find any glyphosate, FDA's own scientists conducted their own tests on their own food they commonly eat and found glyphosate
levels exceeding multiple times the allowed limits in every food they tested
. Keep in mind that even the allowed limits are known to cause cancer in lab animals, but at the levels found in common foods as reported by these scientists the glyphosate's effects are probably going to manifest in a matter of months instead of years." (https://raypeatforum.com/community/threa...ted.23875/