12-19-2016, 06:33 AM
(This post was last modified: 12-19-2016, 06:34 AM by VoS.)
(12-18-2016, 02:12 PM)Arborescence Wrote:
Quote:Aspirin enhanced histamine release from basophils via increased Syk kinase activation, and that the augmentation of histamine release by NSAIDs or FAs may be one possible cause of worsening symptoms in patients with chronic urticaria and FDEIA.
I think that CBD is a really better and more powerful substance than aspirin, and you can get pure crystals of it without PUFA. I will test it to improve my gut and nervous system very soon.
Well, aspirin has been shown to be safe for a very long time, over many decades. One abstract, without any references,* does not make a case against it, based on a supposed receptor signalling pathway:
Quote:When the IgE receptor signaling pathway was activated, aspirin increased the phosphorylation of Syk
If aspirin does enhance a histamine release, that may not be a bad thing. The histamine release may be telling you not to eat that food. Aspirin is amplifying that signal, so that you clearly realize you should not eat it.
The underlying cause of the histamine release is not the aspirin. It's the food you should not be eating.
The gut is the issue. If the gut could be repaired by a diet of emulsified short chain fats, kefir and urea, then the food might not cause the histamine release.
*Edit: It looks like the article and its references are here:
My avatar: William Blake, Vision of Strength
I always have strange sensations when I take aspirin and by that I mean that I don't feel very good. What's interesting is that CBD seems to have all anti-inflammatory effects of aspirin but with no impact on the mucosa and it doesn't seem to release histamine...
Aspirin and most of the cannabinoids look very similar.
For some reason, phenol is magic.
At first glance, it looks like it's context specific. From the study, Aspirin also lowers histamine release "ASPIRIN INHIBITED HISTAMINE RELEASE IN- DUCED BY A23187, fMLP, AND THAPSIGARGIN A23187, fMLP, and thapsigargin also induce hista- mine release from basophils and mast cells by differ- ent mechanisms from anti-IgE21: A23187 directly acti- vates signaling pathways downstream of Ca2+ mobili- zation; fMLP activates a G protein-coupled receptor pathway; and thapsigargin induces Ca2+ influx by de- pletion of intracellular Ca2+ stores. In contrast to aspi- rin augmented IgE-mediated histamine release, 1000 μM of aspirin inhibited histamine release induced by A23187, fMLP, and thapsigargin (Fig. 4)."
I'd also compare results to animal in vivo studies, as this was in vitro. Given that aspirin lowered inflammation in certain circumstances and they never mentioned that in the title or abstract, but only in the body of text, I'd dig into the origin of this study some more. I've read many studies where the data is in conflict with the abstract.